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Granulocyte-colony stimulating factor induced intranuclear endonuclease in murine leukemia cell line.

Abstract:

We have reported that murine leukemia cell line (C2M-A5) induced apoptosis by G-CSF. To clarify the mechanism, mRNA expression of apoptosis-related genes was studied. It revealed transient over-expression of c-myc, H-ras and p53 and down-expression of bcl-2. These changes were known as triggers of endonuclease induction. After 96 h culture with G-CSF, apoptosis was occurred simultaneously with endonuclease (37 kd) activation. This endonuclease induced the digestion of double-strand DNA and mi...

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Publication status:
Published

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Journal:
Leukemia research
Volume:
24
Issue:
12
Pages:
1033-1039
Publication date:
2000-12-01
DOI:
EISSN:
1873-5835
ISSN:
0145-2126
Source identifiers:
311367
Language:
English
Keywords:
Pubs id:
pubs:311367
UUID:
uuid:0a720a82-5139-4da8-b172-966d065bc433
Local pid:
pubs:311367
Deposit date:
2012-12-19

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