Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria.

Journal article

BACKGROUND: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The precise pathophysiology of AKI in falciparum malaria remains unclear. Histopathology shows acute tubular necrosis with localization of host monocytes and parasitized red blood cells in the microvasculature. This study explored the relationship of plasma soluble urokinase-type pla...

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Authors: Plewes, K; Royakkers, A; Hanson, J; Hasan, M; Alam, S

• Publication status: Published
• Publisher: BioMed Central
• Journal: Malaria journal
• Volume: 13
• Issue: 1
• Pages: 91
• Publication date: 2014-01-01
• DOI: 10.1186/1475-2875-13-91
• EISSN: 1475-2875
• ISSN: 1475-2875
• Language: English
• Keywords: Adolescent; Biological Markers; Male; Female; Parasite Load; Antigens, Protozoan; Malaria, Falciparum; Leukocytes, Mononuclear; Middle Aged; Protozoan Proteins; Young Adult; Acute Kidney Injury; Humans; Adult; Animals; Receptors, Urokinase Plasminogen Activator