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Effects of ascent to high altitude on human antimycobacterial immunity

Abstract:

Background Tuberculosis infection, disease and mortality are all less common at high than low altitude and ascent to high altitude was historically recommended for treatment. The immunological and mycobacterial mechanisms underlying the association between altitude and tuberculosis are unclear. We studied the effects of altitude on mycobacteria and antimycobacterial immunity. Methods Antimycobacterial immunity was assayed in 15 healthy adults residing at low altitude before and after they asc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0074220

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Publisher:
Public Library of Science
Journal:
PloS ONE More from this journal
Volume:
8
Issue:
9
Pages:
ARTN e74220
Publication date:
2013-09-13
Acceptance date:
2013-07-29
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:0a67f889-c096-4872-8c98-0aadbf6c6307
Local pid:
pubs:476531
Source identifiers:
476531
Deposit date:
2014-07-24

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