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Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.

Abstract:

Mass spectrometric screening reveals that an unmodified natural heptapeptide--human beta-casomorphin-7, an internal sequence of human beta-casein that possesses opioid-like activity--reacts with porcine pancreatic elastase to form an unusually stable acyl-enzyme complex at low pH. X-ray crystallographic analysis (to 1.9 A resolution) at pH 5 shows continuous electron density linking the C-terminal isoleucine of beta-casomorphin-7 to Ser 195 through an ester bond. The structure reveals a well ...

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Publication status:
Published

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Publisher copy:
10.1038/nsb0697-456

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Journal:
Nature structural biology
Volume:
4
Issue:
6
Pages:
456-462
Publication date:
1997-06-01
DOI:
ISSN:
1072-8368
Source identifiers:
36057
Language:
English
Keywords:
Pubs id:
pubs:36057
UUID:
uuid:0a66a8e5-4fe5-4cc8-9034-28645ec51e8f
Local pid:
pubs:36057
Deposit date:
2012-12-19

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