Journal article
Effects of blood pressure lowering on cardiovascular events, in the context of regression to the mean: a systematic review of randomized trials
- Abstract:
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Objective: To assess the clinical relevance of regression to the mean for clinical trials and clinical practise.
Methods: MEDLINE was searched until February 2018 for randomized trials of BP lowering with over 1000 patient-years follow-up per group. We estimated baseline mean BP, follow-up mean (usual) BP amongst patients grouped by 10 mmHg strata of baseline BP, and assessed effects of BP lowering on coronary heart disease (CHD) and stroke according to these BP levels.
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 107.8KB)
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- Publisher copy:
- 10.1097/HJH.0000000000001994
Authors
Funding
National Institute for Health Research
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National Health and Medical Research Council of Australia
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Bibliographic Details
- Publisher:
- Lippincott, Williams and Wilkins Publisher's website
- Journal:
- Journal of Hypertension Journal website
- Volume:
- 37
- Issue:
- 1
- Pages:
- 16–23
- Publication date:
- 2018-12-18
- Acceptance date:
- 2018-09-25
- DOI:
- EISSN:
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1473-5598
- ISSN:
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0263-6352
Item Description
- Keywords:
- Pubs id:
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pubs:924307
- UUID:
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uuid:0a64d8b1-6d93-44b7-b48b-a575b48f3f60
- Local pid:
- pubs:924307
- Source identifiers:
-
924307
- Deposit date:
- 2018-10-18
Terms of use
- Copyright holder:
- Wolters Kluwer Health, Inc
- Copyright date:
- 2018
- Notes:
- © 2018 Wolters Kluwer Health, Inc. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Lippincott, Williams and Wilkins at: https://doi.org/10.1097/HJH.0000000000001994
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