The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.

Journal article

The 2',5'-oligoadenylate synthetases (OAS) represent a family of interferon-induced proteins implicated in the mechanism of the antiviral action of interferon. When activated by double-stranded RNA, these proteins polymerize ATP into 2'-5'-linked oligomers with the general formula pppA(2'p5'A)n, n >/= 1. Three forms of human OAS corresponding to proteins of 40/46, 69/71, and 100 kDa have been described. Based on the deduced amino acid sequences of the corresponding cDNAs, these OAS share a...

Expand abstract

Authors: Hovnanian, A; Rebouillat, D; Mattei, MG; Levy, E; Marié, I

• Publication status: Published
• Journal: Genomics
• Volume: 52
• Issue: 3
• Pages: 267-277
• Publication date: 1998-09-01
• DOI: 10.1006/geno.1998.5443
• EISSN: 1089-8646
• ISSN: 0888-7543
• Language: English
• Keywords: RNA, Messenger; Sequence Analysis, DNA; 2',5'-Oligoadenylate Synthetase; Humans; Polymerase Chain Reaction; Genetic Markers; Cloning, Molecular; Chromosomes, Human, Pair 12; In Situ Hybridization, Fluorescence; Chromosome Mapping