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Critical role for activation of antigen-presenting cells in priming of cytotoxic T cell responses after vaccination with virus-like particles.

Abstract:

Virus-like particles (VLPs) are known to induce strong Ab responses in the absence of adjuvants. In addition, VLPs are able to prime CTL responses in vivo. To study the efficiency of this latter process, we fused peptide p33 derived from lymphocytic choriomeningitis virus to the hepatitis B core Ag, which spontaneously assembles into VLPs (p33-VLPs). These p33-VLPs were efficiently processed in vitro and in vivo for MHC class I presentation. Nevertheless, p33-VLPs induced weak CTL responses t...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.168.6.2880

Authors


Lechner, F More by this author
Erdmann, I More by this author
Jegerlehner, A More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
168
Issue:
6
Pages:
2880-2886
Publication date:
2002-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:0a55039e-e6af-4f7a-b3f5-4e1ebd31a99e
Source identifiers:
469744
Local pid:
pubs:469744

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