Identifying the genetic determinants of emotionality in humans; insights from rodents.

Journal article

The identification of human quantitative trait genes underlying variation in emotionality has proved to be both difficult and expensive. Whilst several QTL have been consistently identified and independently replicated across both phenotypes and populations, little progression has been made towards the identification of underlying genes or even variants. In this review we discuss the potential for using cross-species QTL concordance as a tool for QTL dissection in behaviour genetics, using an affect-related locus mapped to human chromosome 1 as an example.

Authors: Willis-Owen, SA; Flint, J

• Publication status: Published
• Journal: Neuroscience and biobehavioral reviews
• Volume: 31
• Issue: 1
• Pages: 115-124
• Publication date: 2007-01-01
• DOI: 10.1016/j.neubiorev.2006.07.006
• EISSN: 1873-7528
• ISSN: 0149-7634
• Language: English
• Keywords: Chromosome Mapping; Animals; Phenotype; Genetic Variation; Quantitative Trait Loci; Quantitative Trait, Heritable; Genetics, Behavioral; Models, Animal; Emotions; Chromosomes, Human, Pair 1; Humans; Lod Score