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Amino acid sensing by mTORC1: Intracellular transporters mark the spot.

Abstract:

Cell metabolism and growth are matched to nutrient availability via the amino acid-regulated mechanistic Target of Rapamycin Complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cmet.2016.03.013

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Goberdhan, D
Grant:
AVD08610
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Funding agency for:
Goberdhan, D
Grant:
AVD08610
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Funding agency for:
Wilson, C
Grant:
WT0903326MA
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Funding agency for:
Harris, A
Grant:
C602/A18974
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Publisher:
Cell Press Publisher's website
Journal:
Cell Metabolism Journal website
Volume:
23
Issue:
4
Pages:
580-589
Publication date:
2016-04-01
DOI:
EISSN:
1932-7420
ISSN:
1932-7420
Source identifiers:
615394
Language:
English
Pubs id:
pubs:615394
UUID:
uuid:0a4983ed-309b-4d05-adb1-fffce02acd1f
Local pid:
pubs:615394
Deposit date:
2016-05-29

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