Journal article
Amino acid sensing by mTORC1: Intracellular transporters mark the spot.
- Abstract:
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Cell metabolism and growth are matched to nutrient availability via the amino acid-regulated mechanistic Target of Rapamycin Complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.3MB)
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- Publisher copy:
- 10.1016/j.cmet.2016.03.013
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Wilson, C
Grant:
WT0903326MA
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Metabolism Journal website
- Volume:
- 23
- Issue:
- 4
- Pages:
- 580-589
- Publication date:
- 2016-04-01
- DOI:
- EISSN:
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1932-7420
- ISSN:
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1932-7420
- Source identifiers:
-
615394
Item Description
- Language:
- English
- Pubs id:
-
pubs:615394
- UUID:
-
uuid:0a4983ed-309b-4d05-adb1-fffce02acd1f
- Local pid:
- pubs:615394
- Deposit date:
- 2016-05-29
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Elsevier Inc. Open Access funded by Cancer Research UK under a Creative Commons license
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