Journal article icon

Journal article

Amino acid sensing by mTORC1: Intracellular transporters mark the spot.

Abstract:

Cell metabolism and growth are matched to nutrient availability via the amino acid-regulated mechanistic Target of Rapamycin Complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.cmet.2016.03.013

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More from this funder
Name:
Oxford NHS Biomedical Research Centre
Funding agency for:
Harris, A
Grant:
C602/A18974
More from this funder
Name:
Breast Cancer Research Foundation
Funding agency for:
Harris, A
Grant:
C602/A18974
More from this funder
Name:
Wellcome Trust
Funding agency for:
Wilson, C
Grant:
WT0903326MA
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
Wilson, C
Grant:
WT0903326MA
More from this funder
Name:
John Fell Research Fund
Funding agency for:
Goberdhan, D
Grant:
AVD08610
Publisher:
Cell Press
Journal:
Cell Metabolism More from this journal
Volume:
23
Issue:
4
Pages:
580-589
Publication date:
2016-04-01
DOI:
EISSN:
1932-7420
ISSN:
1932-7420
Language:
English
Pubs id:
pubs:615394
UUID:
uuid:0a4983ed-309b-4d05-adb1-fffce02acd1f
Local pid:
pubs:615394
Source identifiers:
615394
Deposit date:
2016-05-29

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP