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Journal article

Back-priming mode of phi6 RNA-dependent RNA polymerase.

Abstract:

The RNA-dependent RNA polymerase of the double-stranded RNA bacteriophage phi6 is capable of primer-independent initiation, as are many RNA polymerases. The structure of this polymerase revealed an initiation platform, composed of a loop in the C-terminal domain (QYKW, aa 629-632), that was essential for de novo initiation. A similar element has been identified in hepatitis C virus RNA-dependent RNA polymerase. Biochemical studies have addressed the role of this platform, revealing that a mut...

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Publication status:
Published

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Publisher copy:
10.1099/vir.0.80492-0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
The Journal of general virology
Volume:
86
Issue:
Pt 2
Pages:
521-526
Publication date:
2005-02-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:0a446d52-d5a9-40f1-89de-e3042d8c1547
Source identifiers:
12371
Local pid:
pubs:12371

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