- Abstract:
-
The RNA-dependent RNA polymerase of the double-stranded RNA bacteriophage phi6 is capable of primer-independent initiation, as are many RNA polymerases. The structure of this polymerase revealed an initiation platform, composed of a loop in the C-terminal domain (QYKW, aa 629-632), that was essential for de novo initiation. A similar element has been identified in hepatitis C virus RNA-dependent RNA polymerase. Biochemical studies have addressed the role of this platform, revealing that a mut...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1099/vir.0.80492-0
-
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- Journal:
- The Journal of general virology
- Volume:
- 86
- Issue:
- Pt 2
- Pages:
- 521-526
- Publication date:
- 2005-02-05
- DOI:
- EISSN:
-
1465-2099
- ISSN:
-
0022-1317
- URN:
-
uuid:0a446d52-d5a9-40f1-89de-e3042d8c1547
- Source identifiers:
-
12371
- Local pid:
- pubs:12371
- Copyright date:
- 2005
Journal article
Back-priming mode of phi6 RNA-dependent RNA polymerase.
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