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Journal article

T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2.

Abstract:

T3-associated disulphide linked heterodimers (Tin) comprised of clonally unique alpha-chains of molecular weight (MW) 49,000-54,000 and beta chains of MW 43,000 have been identified as the antigen receptors on human cytotoxic effector and inducer T-lymphocytes. Crosslinking of Ti molecules by either the appropriate nominal antigen/MHC specificity or anti-clonotypic monoclonal antibody results in clonal expansion of such cells via induction of IL-2 receptor expression, endogenous IL-2 release ...

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Publication status:
Published

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Publisher copy:
10.1038/311565a0

Authors


Bensussan, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Hussey, RE More by this author
Milanese, C More by this author
Reinherz, EL More by this author
Journal:
Nature
Volume:
311
Issue:
5986
Pages:
565-567
Publication date:
1984
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:0a43832c-9877-4771-8fe5-c94a5e086766
Source identifiers:
14394
Local pid:
pubs:14394

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