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Journal article

Active genes are tri-methylated at K4 of histone H3.

Abstract:

Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl. Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions but not in silent heterochromatic sites. Here we show that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes. Using antibodies that discriminate between the di- and tri-methylated state of K4 we show that di-methylation occurs at both ina...

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Publication status:
Published

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Publisher copy:
10.1038/nature01080

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Journal:
Nature
Volume:
419
Issue:
6905
Pages:
407-411
Publication date:
2002-09-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:0a42a91f-5065-440c-9313-1fefd65e0938
Source identifiers:
101229
Local pid:
pubs:101229

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