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SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study

Abstract:

Background A newly-described syndrome called Aneurysm-Osteoarthritis Syndrome (AOS) was recently reported. AOS presents with early onset osteoarthritis (OA) in multiple joints, together with aneurysms in major arteries, and is caused by rare mutations in SMAD3. Because of the similarity of AOS to idiopathic generalized OA (GOA), we hypothesized that SMAD3 is also associated with GOA and tested the hypothesis in a population-based cohort. Methods Study participants were derived from the Chingf...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0097786

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Publisher:
Public Library of Science
Journal:
PloS ONE More from this journal
Volume:
9
Issue:
5
Pages:
ARTN e97786
Publication date:
2014-05-22
Acceptance date:
2014-04-23
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:0a40d35e-5758-400e-9c7d-6209b0b22de6
Local pid:
pubs:465944
Source identifiers:
465944
Deposit date:
2014-06-26

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