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MDM2 and MDMX bind and stabilize the p53-related protein p73

Abstract:

The p53 gene encodes one of the most important tumor suppressors in human cells and undergoes frequent mutational inactivation in cancers. MDM2, a transcriptional target of p53, binds p53 and can both inhibit p53-mediated transcription [1], [2] and target p53 for proteasome-mediated proteolysis [3], [4]. A close relative of p53, p73, has recently been identified [5], [6]. Here, we report that, like p53, p73α and the alternative transcription product p73β also bind MDM2. Interaction between MD...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S0960-9822(99)80367-4

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Institution:
University of Oxford
Oxford college:
Oriel College
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Current biology : CB Journal website
Volume:
9
Issue:
15
Pages:
829-832
Publication date:
1999-07-01
Acceptance date:
1999-06-23
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Pmid:
10469568
Source identifiers:
28788
Language:
English
Keywords:
Pubs id:
pubs:28788
UUID:
uuid:0a3a4b83-2eca-4c0e-97d7-fb7538e10d25
Local pid:
pubs:28788
Deposit date:
2017-01-27

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