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Analysis of Ipl1-mediated phosphorylation of the Ndc80 kinetochore protein in Saccharomyces cerevisiae.

Abstract:
Phosphorylation of the Ndc80 kinetochore protein by the Ipl1/Aurora B kinase reduces its microtubule binding activity in vitro. We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential. Instead, we show that additional Ipl1 targets contribute to segregation and the spindle checkpoint.

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Publisher copy:
10.1534/genetics.109.109041

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Nelson, CR More by this author
Ranish, JA More by this author
Biggins, S More by this author
Journal:
Genetics
Volume:
183
Issue:
4
Pages:
1591-1595
Publication date:
2009-12-05
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
URN:
uuid:0a38b776-e788-4aa1-90bd-4278af063f58
Source identifiers:
228688
Local pid:
pubs:228688

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