Autoantibodies in thymoma-associated myasthenia gravis with myositis or neuromyotonia.

Journal article

BACKGROUND: About 50% of patients with thymoma have paraneoplastic myasthenia gravis (MG). Myositis and myocarditis or neuromyotonia (NMT) will also develop in some. Patients with thymoma-associated MG produce autoantibodies to a variety of neuromuscular antigens, particularly acetylcholine receptor (AChR), titin, skeletal muscle calcium release channel (ryanodine receptor [RyR]), and voltage-gated potassium channels (VGKC). OBJECTIVE: To examine whether neuromuscular autoantibodies in patien...

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Authors: Mygland, A; Vincent, A; Newsom-Davis, J; Kaminski, H; Zorzato, F

• Publication status: Published
• Journal: Archives of neurology
• Volume: 57
• Issue: 4
• Pages: 527-531
• Publication date: 2000-04-01
• DOI: 10.1001/archneur.57.4.527
• EISSN: 1538-3687
• ISSN: 0003-9942
• Language: English
• Keywords: Potassium Channels; Muscle Proteins; Myositis; Paraneoplastic Syndromes; Protein Kinases; Autoantibodies; Ryanodine Receptor Calcium Release Channel; Thymus Neoplasms; Myasthenia Gravis; Aged; Thymoma; Humans; Adult; Female; Male; Myocarditis; Carcinoid Tumor; Predictive Value of Tests; Receptors, Cholinergic; Electromyography; Middle Aged; Comorbidity; Isaacs Syndrome