Journal article icon

Journal article

Gamma-vinyl GABA reduces paired pulse inhibition in the rat dentate gyrus in vivo and in vitro.

Abstract:

Gamma vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, has anticonvulsant effects. GVG increases GABA levels in the brain by blocking its degradation, and is presumed to enhance GABAergic inhibition, however, in some cases it exacerbates seizures. We investigated the effects of GVG in vivo and in vitro on paired pulse inhibition (PPI) recorded in the rat dentate gyrus (DG) evoked by perforant path stimulation. At 2.5 h and 24 h after administration of GVG (1 g/kg, i.p.), there w...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Epilepsy research More from this journal
Volume:
44
Issue:
2-3
Pages:
109-117
Publication date:
2001-05-01
DOI:
EISSN:
1872-6844
ISSN:
0920-1211
Language:
English
Keywords:
Pubs id:
pubs:430774
UUID:
uuid:0a28c040-33d8-402c-80eb-fc08175d9818
Local pid:
pubs:430774
Source identifiers:
430774
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP