Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.

Journal article

Regulatory T cells (T(reg)) play an important role in immune regulation. Their development in the thymus requires TCR activation and recognition of peptide-MHC, although the downstream signals controlling commitment to the lineage are unclear. To compare the requirements for positive selection and T(reg) development, we studied knockout and transgenic mice defective in Raf signaling and the ERK effector SRF accessory protein 1 (SAP-1), a member of the ternary complex factor family of Ets doma...

Expand abstract

Authors: Willoughby, J; Costello, P; Nicolas, R; Robinson, N; Stamp, G

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 179
• Issue: 10
• Pages: 6836-6844
• Publication date: 2007-11-01
• DOI: 10.4049/jimmunol.179.10.6836
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: ets-Domain Protein Elk-4; Early Growth Response Protein 1; Colitis; Gene Expression Regulation; T-Lymphocytes, Regulatory; Cell Proliferation; Antigens, Differentiation; Disease Models, Animal; Animals; Thymus Gland; Extracellular Signal-Regulated MAP Kinases; Mice, Transgenic; Signal Transduction; Mice; raf Kinases