Journal article
A total synthesis of salinosporamide A
- Abstract:
- Salinosporamide A is a β‐lactone proteasome inhibitor currently in clinical trials for the treatment of multiple‐myeloma. Herein we report a short synthesis of this small, highly functionalized, biologically important natural product that uses an oxidative radical cyclization as a key step and allows for the preparation of gram quantities of advanced synthetic intermediates.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 5.9MB, Terms of use)
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(Preview, Accepted manuscript, pdf, 742.1KB, Terms of use)
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- Publisher copy:
- 10.1002/chem.201800046
Authors
- Publisher:
- Wiley
- Journal:
- Chemistry - A European Journal More from this journal
- Volume:
- 24
- Issue:
- 26
- Pages:
- 6747-6754
- Publication date:
- 2018-03-09
- Acceptance date:
- 2018-02-01
- DOI:
- EISSN:
-
1521-3765
- ISSN:
-
0947-6539
- Keywords:
- Pubs id:
-
pubs:823086
- UUID:
-
uuid:0a25806e-f4d2-49ad-baba-dd24dd0c558c
- Local pid:
-
pubs:823086
- Source identifiers:
-
823086
- Deposit date:
-
2018-02-07
- ARK identifier:
Terms of use
- Copyright holder:
- Wiley‐VCH Verlag GmbH & Co KGaA, Weinheim
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/chem.201800046
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