- Abstract:
-
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite-time profile provide a valuable decision tool for determining dosing regimens for anti-malarial treatments, as well as a formative component of population-level drug resistance models. We reviewed published anti-malarial pharmacokinetic-pharmacodynamic models to identify the challenges for these complex models where parameter estimation from clinical field data is limited. The inclusion of key...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1208/s12248-014-9647-y
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- Journal:
- The AAPS journal
- Volume:
- 16
- Issue:
- 5
- Pages:
- 962-974
- Publication date:
- 2014-09-05
- DOI:
- EISSN:
-
1550-7416
- ISSN:
-
1550-7416
- URN:
-
uuid:0a24c3f3-252d-4336-a79c-2d235c82278a
- Source identifiers:
-
478264
- Local pid:
- pubs:478264
- Language:
- English
- Keywords:
- Copyright date:
- 2014
Journal article
Making the most of clinical data: reviewing the role of pharmacokinetic-pharmacodynamic models of anti-malarial drugs.
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