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Making the most of clinical data: reviewing the role of pharmacokinetic-pharmacodynamic models of anti-malarial drugs.

Abstract:

Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite-time profile provide a valuable decision tool for determining dosing regimens for anti-malarial treatments, as well as a formative component of population-level drug resistance models. We reviewed published anti-malarial pharmacokinetic-pharmacodynamic models to identify the challenges for these complex models where parameter estimation from clinical field data is limited. The inclusion of key...

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Publication status:
Published

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Publisher copy:
10.1208/s12248-014-9647-y

Authors


Simpson, JA More by this author
Zaloumis, S More by this author
DeLivera, AM More by this author
Journal:
The AAPS journal
Volume:
16
Issue:
5
Pages:
962-974
Publication date:
2014-09-05
DOI:
EISSN:
1550-7416
ISSN:
1550-7416
URN:
uuid:0a24c3f3-252d-4336-a79c-2d235c82278a
Source identifiers:
478264
Local pid:
pubs:478264

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