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Characterization of four substrates emphasizes kinetic similarity between insect and human C-domain angiotensin-converting enzyme.

Abstract:

Angiotensin converting enzyme (ACE) was already discovered in insects in 1994, but its physiological role is still enigmatic. We have addressed this problem by purifying four new ACE substrates from the ovaries of the grey fleshfly, Neobellieria bullata. Their primary structures were identified as NKLKPSQWISLSD (Neb-ODAIF-1(1-13)), NKLKPSQWI (Neb-ODAIF-1(1-9)), SLKPSNWLTPSE (Neb-ODAIF-2) and LEQIYHL. Database analysis showed significant homology with amino acid sequence stretches as present i...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Vandingenen, A More by this author
Macours, N More by this author
Baggerman, G More by this author
Karaoglanovic, AC More by this author
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Journal:
European journal of biochemistry / FEBS
Volume:
269
Issue:
14
Pages:
3522-3530
Publication date:
2002-07-05
DOI:
EISSN:
1432-1033
ISSN:
0014-2956
URN:
uuid:0a19ddb4-be6d-40cc-b236-607e12fdd8ac
Source identifiers:
345839
Local pid:
pubs:345839

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