Inflammatory Ly-6Chi monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients

Journal article

Objective: Transplant arteriosclerosis (TA) restricts long-term survival of heart transplant recipients. Although the role of monocyte/macrophages is well established in native atherosclerosis, it has been studied to a much lesser extent in TA. Plasma cholesterol is the most important non-immunologic risk factor for development of TA but the underlying mechanisms are largely unknown. We hypothesized that monocyte/macrophages might play an important role in the pathogenesis of TA under hyperli...

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Authors: Schiopu, A; Nadig, SN; Cotoi, O; Hester, J; Van Rooijen, N

• Journal: Atherosclerosis
• Volume: 223
• Issue: 2
• Pages: 291-298
• Publication date: 2012-08-01
• DOI: 10.1016/j.atherosclerosis.2012.05.010
• EISSN: 1879-1484
• ISSN: 0021-9150
• Language: English
• Keywords: Hypercholesterolemia; Macrophages; Inflammation; Transplant vasculopathy; Monocytes