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Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors.

Abstract:

BACKGROUND: There has been much research into the use of RNA interference (RNAi) for the treatment of human diseases. Many viruses, including hepatitis B virus (HBV), are susceptible to inhibition by this mechanism. However, for RNAi to be effective therapeutically, a suitable delivery system is required. METHODS: Here we identify an RNAi sequence active against the HBV surface antigen (HBsAg), and demonstrate its expression from a polymerase III expression cassette. The expression cassette ...

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Publisher copy:
10.1002/jgm.739

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
McGarvey, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Cullen, BR More by this author
McClure, MO More by this author
Journal:
The journal of gene medicine
Volume:
7
Issue:
7
Pages:
918-925
Publication date:
2005-07-05
DOI:
EISSN:
1521-2254
ISSN:
1099-498X
URN:
uuid:0a1833b6-d734-41ca-a9c3-6377d2e5b820
Source identifiers:
228590
Local pid:
pubs:228590

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