- Abstract:
-
Angiogenesis is an attractive target for cancer therapy, due to its central position in tumor growth and development. Vascular Endothelial Growth Factor (VEGF) and its receptors (VEGFRs) play a key role in the angiogenic process. A promising strategy for targeting VEGF-mediated angiogenesis is RNA interference (RNAi) using short interfering RNA (siRNA). However, for efficacious RNAi a well-designed siRNA delivery system is crucial. Liposome-Polycation-DNA (LPD) particles form a promising syst...
Expand abstract - Publisher copy:
- 10.1016/j.jconrel.2011.09.080
-
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- Journal:
- Journal of controlled release : official journal of the Controlled Release Society
- Volume:
- 160
- Issue:
- 2
- Pages:
- 211-216
- Publication date:
- 2012-06-05
- DOI:
- EISSN:
-
1873-4995
- ISSN:
-
0168-3659
- URN:
-
uuid:0a115f55-bf27-4f0c-85e6-839afdf38fe4
- Source identifiers:
-
345852
- Local pid:
- pubs:345852
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles.
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