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Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles.

Abstract:

Angiogenesis is an attractive target for cancer therapy, due to its central position in tumor growth and development. Vascular Endothelial Growth Factor (VEGF) and its receptors (VEGFRs) play a key role in the angiogenic process. A promising strategy for targeting VEGF-mediated angiogenesis is RNA interference (RNAi) using short interfering RNA (siRNA). However, for efficacious RNAi a well-designed siRNA delivery system is crucial. Liposome-Polycation-DNA (LPD) particles form a promising syst...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Crielaard, BJ More by this author
van Dommelen, SM More by this author
van der Meel, R More by this author
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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
160
Issue:
2
Pages:
211-216
Publication date:
2012-06-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:0a115f55-bf27-4f0c-85e6-839afdf38fe4
Source identifiers:
345852
Local pid:
pubs:345852

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