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Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

Abstract:

Bromodomain-containing proteins of the BET family recognize histone lysine acetylation and mediate transcriptional activation of target genes such as the MYC oncogene. Pharmacological inhibitors of BET domains promise therapeutic benefits in a variety of cancers. We performed a high-diversity chemical compound screen for agents capable of modulating BRD4-dependent heterochromatization of a generic reporter in human cells. In addition to known and new compounds targeting BRD4, we identified sm...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nchembio.2080

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Publisher:
Nature Publishing Group
Journal:
Nature Chemical Biology More from this journal
Volume:
12
Pages:
504–510
Publication date:
2016-05-09
Acceptance date:
2016-03-18
DOI:
ISSN:
1552-4450
Keywords:
Pubs id:
pubs:622522
UUID:
uuid:0a004f44-4a54-4260-ae0b-98bef7c97cd9
Local pid:
pubs:622522
Source identifiers:
622522
Deposit date:
2016-05-17

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