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Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study.

Abstract:

Aromatase inhibitor (AI)-associated arthralgia limits adherence to therapy in breast cancer. The pathophysiology may involve vitamin D status. We wished to establish the optimal concentration of 25(OH)D that prevents or minimizes arthralgia. We used a prospective cohort of 290 women starting AI in whom baseline vitamin D was measured. All received daily vitamin D(3) (800 IU) with calcium. Women with baseline 25(OH)D concentration <30 ng/ml also received 16,000 IU of D(3) orally every 2 wee...

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Publisher copy:
10.1007/s10549-010-1075-9

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Breast Cancer Res Treat More from this journal
Volume:
125
Issue:
3
Pages:
869-878
Place of publication:
Netherlands
Publication date:
2011-02-01
DOI:
EISSN:
1573-7217
ISSN:
0167-6806
Language:
English
Keywords:
Pubs id:
pubs:118137
UUID:
uuid:09fe68b6-1da7-4153-8b05-8c3bc933fcab
Local pid:
pubs:118137
Source identifiers:
118137
Deposit date:
2012-12-19

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