Journal article

First asymmetric synthesis of the Kelatorphan-like enkephalinase inhibitor (1S,2R,2 ' S)-2-[2 '-(N-hydroxycarbamoylmethyl)-3 '-phenylpropionylamino]cyclohexane-1-carboxylic acid

Abstract:: The first asymmetric synthesis of Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S)-2-[2′-(N-hydroxycarbamoylmethyl)-3′- phenylpropionylamino]cyclohexane-1-carboxylic acid is achieved using lithium amide (R)-5 and pyrrolidinone auxiliary (R)-6; the pyrrolidinone auxiliary is used to create (2S)-benzylsuccinic acid derivative (S)-4 while lithium amide (R)-5 is used to synthesize tert-butyl (1S,2R)-2-aminocyclohexanecarboxylate 3.

Publication status:: Published

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APA Style

Davies, S., & Dixon, D. (1998). First asymmetric synthesis of the Kelatorphan-like enkephalinase inhibitor (1S,2R,2 ' S)-2-[2 '-(N-hydroxycarbamoylmethyl)-3 '-phenylpropionylamino]cyclohexane-1-carboxylic acid. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 17, 2629–2634.

MLA Style

Davies, S, and D Dixon. “First Asymmetric Synthesis of the Kelatorphan-like Enkephalinase Inhibitor (1S,2R,2 ' S)-2-[2 '-(N-Hydroxycarbamoylmethyl)-3 '-Phenylpropionylamino]Cyclohexane-1-Carboxylic Acid.” JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, no. 17, 1998, pp. 2629–34.

Chicago Style

Davies, S, and D Dixon. 1998. “First Asymmetric Synthesis of the Kelatorphan-like Enkephalinase Inhibitor (1S,2R,2 ' S)-2-[2 '-(N-Hydroxycarbamoylmethyl)-3 '-Phenylpropionylamino]Cyclohexane-1-Carboxylic Acid.” JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, no. 17: 2629–34.
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Publisher copy:: 10.1039/a804660c

Authors

+ Davies, S More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Dixon, D More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 More from this journal
Issue:: 17
Pages:: 2629-2634
Publication date:: 1998-09-07
DOI:: 10.1039/a804660c
EISSN:: 1364-5463
ISSN:: 0300-922X

Language:: English
Pubs id:: pubs:36612
UUID:: uuid:09eed45a-4bb5-4f97-9529-0eddb61cbbac
Local pid:: pubs:36612
Source identifiers:: 36612
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_09eed45a4bb54f9795290eddb61cbbac

Terms of use

Copyright date:: 1998

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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