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Proteasome assembly triggers a switch required for active-site maturation.

Abstract:

The processing of propeptides and the maturation of 20S proteasomes require the association of beta rings from two half proteasomes. We propose an assembly-dependent activation model in which interactions between helix (H3 and H4) residues of the opposing half proteasomes are prerequisite for appropriate positioning of the S2-S3 loop; such positioning enables correct coordination of the active-site residue needed for propeptide cleavage. Mutations of H3 or H4 residues that participate in the ...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2006.05.019

Authors


Journal:
Structure (London, England : 1993) More from this journal
Volume:
14
Issue:
7
Pages:
1179-1188
Publication date:
2006-07-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
Keywords:
Pubs id:
pubs:59425
UUID:
uuid:09ee6f7b-217c-4d77-a780-777da9a51e36
Local pid:
pubs:59425
Source identifiers:
59425
Deposit date:
2012-12-19

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