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Stearoyl-CoA desaturase: rogue or innocent bystander?

Abstract:

Different lipid fractions in humans have characteristic fatty acid profiles and these are maintained partly through diet and to a lesser extent through endogenous synthesis. The enzyme stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids such as palmitoleic acid (16:1 n-7) and oleic acid (18:1 n-9). These are the two most abundant monounsaturated fatty acids in human plasma lipids, membranes and adipose tissue. Although in qua...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Progress in lipid research More from this journal
Volume:
52
Issue:
1
Pages:
15-42
Publication date:
2013-01-01
DOI:
EISSN:
1873-2194
ISSN:
0163-7827
Language:
English
Keywords:
Pubs id:
pubs:352396
UUID:
uuid:09ed22eb-54cd-4821-9546-ac174e8af5b6
Local pid:
pubs:352396
Source identifiers:
352396
Deposit date:
2013-11-16

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