The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers.

Journal article

Results from animal studies have suggested that serotonin (5-HT) antagonists acting on the 5-HT3 receptor may have anxiolytic properties. We have assessed whether pretreatment with the 5-HT3 receptor antagonist BRL 46470 (1 mg orally) attenuates the increase in anxiety induced in healthy volunteers by intravenous infusion of m-chlorophenylpiperazine (mCPP: 0.08 mg/kg over 2 min). In this double-blind placebo-controlled crossover study in 12 healthy men who were volunteers, infusion of mCPP ca...

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Authors: Silverstone, P; Cowen, P

• Publication status: Published
• Journal: Biological psychiatry
• Volume: 36
• Issue: 5
• Pages: 309-316
• Publication date: 1994-09-01
• DOI: 10.1016/0006-3223(94)90628-9
• EISSN: 1873-2402
• ISSN: 0006-3223
• Language: English
• Keywords: Serotonin Antagonists; Middle Aged; Bicyclo Compounds, Heterocyclic; Brain; Piperazines; Infusions, Intravenous; Serotonin Receptor Agonists; Male; Hydrocortisone; Administration, Oral; Anti-Anxiety Agents; Adolescent; Double-Blind Method; Anxiety; Bicyclo Compounds; Premedication; Prolactin; Adult; Humans; Panic; Receptors, Serotonin; Cross-Over Studies; Indoles