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Dia2 controls transcription by mediating assembly of the RSC complex.

Abstract:

BACKGROUND: Dia2 is an F-box protein found in the budding yeast, S. cerevisiae. Together with Skp1 and Cul1, Dia2 forms the substrate-determining part of an E3 ubiquitin ligase complex, otherwise known as the SCF. Dia2 has previously been implicated in the control of replication and genome stability via its interaction with the replisome progression complex. PRINCIPAL FINDINGS: We identified components of the RSC chromatin remodelling complex as genetic interactors with Dia2, suggesting an ad...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0021172

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
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Name:
NIHR Biomedical Research Centre Oxford
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Name:
Computational Biology Research Group (University of Oxford)
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
6
Issue:
6
Article number:
e21172
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:09e20e29-4455-4869-a931-81e1291b44f9
Local pid:
pubs:164106
Source identifiers:
164106
Deposit date:
2012-12-19

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