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Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.

Abstract:

A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha4beta7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20080414

Authors


Jaensson, E More by this author
Uronen-Hansson, H More by this author
Eksteen, B More by this author
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Journal:
The Journal of experimental medicine
Volume:
205
Issue:
9
Pages:
2139-2149
Publication date:
2008-09-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:09dd96d4-c520-4143-bdfd-18e54510fb3e
Source identifiers:
25723
Local pid:
pubs:25723

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