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Dexamethasone mimics aspects of physiological acclimatization to 8 hours of hypoxia but suppresses plasma erythropoietin.

Abstract:

Dexamethasone ameliorates the severity of acute mountain sickness (AMS) but it is unknown whether it obtunds normal physiological responses to hypoxia. We studied whether dexamethasone enhanced or inhibited the ventilatory, cardiovascular, and pulmonary vascular responses to sustained (8 h) hypoxia. Eight healthy volunteers were studied, each on four separate occasions, permitting four different protocols. These were: dexamethasone (20 mg orally) beginning 2 h before a control period of 8 h o...

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Publication status:
Published

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Journal:
Journal of applied physiology (Bethesda, Md. : 1985) More from this journal
Volume:
114
Issue:
7
Pages:
948-956
Publication date:
2013-04-01
DOI:
EISSN:
1522-1601
ISSN:
8750-7587
Language:
English
Keywords:
Pubs id:
pubs:384161
UUID:
uuid:09da5fd1-6cc9-4f44-86df-ed13f8283aab
Local pid:
pubs:384161
Source identifiers:
384161
Deposit date:
2013-11-16

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