Journal article icon

Journal article

Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells

Abstract:

Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characteriz...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1172/jci.insight.147929

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
H4 RDM CLINICAL LABORATORY SCIENCES; HE WOMEN’S & REPRODUCTIVE HEALTH
Role:
Author
ORCID:
0000-0002-4780-3199
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
ORCID:
0000-0002-1688-6032
More by this author
Role:
Author
ORCID:
0000-0002-6121-8893
More by this author
Role:
Author
ORCID:
0000-0001-5475-9061
Publisher:
American Society for Clinical Investigation
Journal:
JCI Insight More from this journal
Volume:
6
Issue:
11
Article number:
e147929
Publication date:
2021-05-04
Acceptance date:
2021-04-29
DOI:
EISSN:
2379-3708
Language:
English
Keywords:
Pubs id:
1174269
Local pid:
pubs:1174269
Deposit date:
2021-05-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP