Journal article
Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells
- Abstract:
-
Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characteriz...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI Insight Journal website
- Volume:
- 6
- Issue:
- 11
- Article number:
- e147929
- Publication date:
- 2021-05-04
- Acceptance date:
- 2021-04-29
- DOI:
- EISSN:
-
2379-3708
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1174269
- Local pid:
- pubs:1174269
- Deposit date:
- 2021-05-05
Terms of use
- Copyright holder:
- Artibani et al.
- Copyright date:
- 2021
- Rights statement:
- ©2020 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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