Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial.

Journal article

BACKGROUND: Among patients with substantial carotid artery narrowing but no recent neurological symptom (stroke or transient ischaemia), the balance of surgical risks and long-term benefits from carotid endarterectomy (CEA) was unclear. METHODS: During 1993-2003, 3120 asymptomatic patients with substantial carotid narrowing were randomised equally between immediate CEA (half got CEA by 1 month, 88% by 1 year) and indefinite deferral of any CEA (only 4% per year got CEA) and were followed for ...

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Authors: Halliday, A; Mansfield, A; Marro, J; Peto, C; Peto, R

• Publication status: Published
• Journal: Lancet
• Volume: 363
• Issue: 9420
• Pages: 1491-1502
• Publication date: 2004-05-01
• DOI: 10.1016/s0140-6736(04)16146-1
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Humans; MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group; Stroke; Risk Factors; Male; Time Factors; Aged; Endarterectomy, Carotid; Survival Rate; Ischemic Attack, Transient; Female; Carotid Stenosis; Aged, 80 and over