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HIV-1 Populations in Semen Arise through Multiple Mechanisms.

Abstract:

HIV-1 is present in anatomical compartments and bodily fluids. Most transmissions occur through sexual acts, making virus in semen the proximal source in male donors. We find three distinct relationships in comparing viral RNA populations between blood and semen in men with chronic HIV-1 infection, and we propose that the viral populations in semen arise by multiple mechanisms including: direct import of virus, oligoclonal amplification within the seminal tract, or compartmentalization. In ad...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1001053

Authors


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Name:
National Institutes of Health
Grant:
P30 AI50410
Publisher:
Public Library of Science
Journal:
PLoS pathogens More from this journal
Volume:
6
Issue:
8
Pages:
e1001053
Publication date:
2010-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Language:
English
Keywords:
Pubs id:
pubs:71146
UUID:
uuid:09c9b6d5-4f71-4535-9db3-360f14797eae
Local pid:
pubs:71146
Source identifiers:
71146
Deposit date:
2012-12-19

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