A comparison of two formulations of indomethacin ('Flexin Continus' tablets and 'Indocid' capsules) in the treatment of osteoarthritis.

Journal article

The efficacy and side-effect profiles of two formulations of indomethacin were compared in a multi-centre, double-blind, crossover study in 77 patients with osteoarthritis. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times daily for a period of 4 weeks, after which patients were crossed over to receive the alternative treatment for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by the investigator and patient indicate that controlled-release indomethacin tablets, 75 mg given at night, were as efficacious as immediate-release indomethacin capsules, 25 mg given 3-times daily, in the treatment of osteoarthritis. The side-effect profiles of the two formulations were similar.

Authors: Bacon, P; Luqmani, R; Bossingham, D; Daymond, T; Grahame, R

• Publication status: Published
• Publisher: Informa Healthcare
• Journal: Current medical research and opinion
• Volume: 12
• Issue: 2
• Pages: 128-134
• Publication date: 1990-01-01
• DOI: 10.1185/03007999009110481
• EISSN: 1473-4877
• ISSN: 0300-7995
• Language: English
• Keywords: Tablets; Humans; Randomized Controlled Trials as Topic; Osteoarthritis, Hip; Osteoarthritis; Multicenter Studies as Topic; Knee Joint; Delayed-Action Preparations; Administration, Oral; Double-Blind Method; Indomethacin; Capsules; Drug Administration Schedule