Three-dimensional structure of herpes simplex virus from cryo-electron tomography.

Journal article

Herpes simplex virus, a DNA virus of high complexity, consists of a nucleocapsid surrounded by the tegument-a protein compartment-and the envelope. The latter components, essential for infectivity, are pleiomorphic. Visualized in cryo-electron tomograms of isolated virions, the tegument was seen to form an asymmetric cap: On one side, the capsid closely approached the envelope; on the other side, they were separated by approximately 35 nanometers of tegument. The tegument substructure was par...

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Authors: Grünewald, K; Desai, P; Winkler, D; Heymann, J; Belnap, D

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 302
• Issue: 5649
• Pages: 1396-1398
• Publication date: 2003-11-01
• DOI: 10.1126/science.1090284
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Virion; Herpesvirus 1, Human; Cercopithecus aethiops; Vero Cells; Capsid; Cryoelectron Microscopy; Image Processing, Computer-Assisted; Tomography; Humans; Viral Envelope Proteins; Animals; Nucleocapsid; Lipid Bilayers