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Journal article

The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms.

Abstract:

One proposed HIV vaccine strategy is to induce Gag-specific CD8(+) T-cell responses that can corner the virus, through fitness cost of viral escape and unavailability of compensatory mutations. We show here that the most variable capsid residues principally comprise escape mutants driven by protective alleles HLA-B*57, -5801, and -8101 and covarying HLA-independent polymorphisms that arise in conjunction with these escape mutations. These covarying polymorphisms are potentially compensatory a...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01879-10

Authors


Journal:
Journal of virology
Volume:
85
Issue:
3
Pages:
1384-1390
Publication date:
2011-02-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:191292
UUID:
uuid:09be861d-5374-44ed-affe-33970e45040c
Local pid:
pubs:191292
Source identifiers:
191292
Deposit date:
2012-12-19

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