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Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay.

Abstract:

Cell-penetrating peptides (CPPs) have shown great potency for cargo delivery both in vitro and in vivo. Different biologically relevant molecules need to be delivered into appropriate cellular compartments in order to be active, for instance certain drugs/molecules, e.g. antisense oligonucleotides, peptides, and cytotoxic agents require delivery into the cytoplasm. Assessing uptake mechanisms of CPPs can help to develop novel and more potent cellular delivery vectors, especially in cases when...

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
Journal:
Biochimica et biophysica acta
Volume:
1798
Issue:
3
Pages:
338-343
Publication date:
2010-03-01
DOI:
ISSN:
0006-3002
Source identifiers:
266894
Language:
English
Keywords:
Pubs id:
pubs:266894
UUID:
uuid:09b3c240-8449-4a60-a836-289f9325e437
Local pid:
pubs:266894
Deposit date:
2012-12-19

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