TNFAIP6 and SAA1 mRNA levels are elevated in peripheral blood cells following destabilising knee injuries

Journal article

Purpose: Acute destabilising injury to the joint is a considerable risk for the development of osteoarthritis (OA); about 50% of individuals with such injuries will develop OA within 5 to 10 years. It is currently impossible to predict whether an individual with an acute destabilising joint injury will develop OA or not. Our previous work in mice has revealed a number of highly mechanosensitive genes/pathways that are regulated early upon surgical destabilization of the medial meniscus (DMM). As many of the genes identified were ubiquitously expressed, inflammatory response genes, we asked whether they were also regulated in the cellular compartment of the peripheral blood. Finally, we examined whether genes that were regulated in the mouse blood upon DMM were also regulated in the peripheral blood of patients who had recently sustained a destabilising knee injury.

Authors: Chanalaris, A; Paterson, E; Freidin, A; Kenny, M; Saklatvala, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Osteoarthritis and Cartilage
• Volume: 24
• Issue: Suppl. 1
• Pages: S82–S83
• Publication date: 2016-04-01
• DOI: 10.1016/j.joca.2016.01.175
• ISSN: 1063-4584
• Keywords: SBTMR