Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians.

Journal article

The role of the CTLA-4 antigen in the development of autoimmune diseases is well documented, with several autoimmune disorders showing association or linkage with the CTLA-4 locus. Its role in the aetiology of rheumatoid arthritis (RA) however, remains unclear, as the functional studies of the B7-CTLA-4 pathway in mouse models of RA and genetic studies in humans have given contrasting results. We have studied the single nucleotide polymorphism at position +49 (A/G) of the CTLA-4 gene, in a co...

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Authors: Milicic, A; Brown, M; Wordsworth, B

• Publication status: Published
• Journal: Tissue antigens
• Volume: 58
• Issue: 1
• Pages: 50-54
• Publication date: 2001-07-01
• DOI: 10.1034/j.1399-0039.2001.580110.x
• EISSN: 1399-0039
• ISSN: 0001-2815
• Language: English
• Keywords: European Continental Ancestry Group; Polymorphism, Genetic; CTLA-4 Antigen; Guanosine; Great Britain; Immunoconjugates; Adenosine; Genetic Predisposition to Disease; Antigens, Differentiation; Antigens, CD; Humans; Codon; Arthritis, Rheumatoid