Journal article icon

Journal article

Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages.

Abstract:

Pulmonary surfactant protein-D (SP-D) is a multifunctional, pattern recognition molecule involved in resistance to allergen challenge and pulmonary inflammation. In view of therapeutic effects of exogenous SP-D or recombinant fragment of human surfactant protein-D (rhSP-D) (composed of eight Gly-X-Y collagen repeat sequences, homotrimeric neck and lectin domains) in murine models of lung allergy and hypereosinophilic SP-D gene-deficient mice, we investigated the possibility of a direct intera...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/intimm/dxn058

Authors


Journal:
International immunology More from this journal
Volume:
20
Issue:
8
Pages:
993-1007
Publication date:
2008-08-01
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
Language:
English
Keywords:
Pubs id:
pubs:243314
UUID:
uuid:09a53c6e-df97-411b-9f76-66abfb034eae
Local pid:
pubs:243314
Source identifiers:
243314
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP