Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages.

Journal article

Pulmonary surfactant protein-D (SP-D) is a multifunctional, pattern recognition molecule involved in resistance to allergen challenge and pulmonary inflammation. In view of therapeutic effects of exogenous SP-D or recombinant fragment of human surfactant protein-D (rhSP-D) (composed of eight Gly-X-Y collagen repeat sequences, homotrimeric neck and lectin domains) in murine models of lung allergy and hypereosinophilic SP-D gene-deficient mice, we investigated the possibility of a direct intera...

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Authors: Mahajan, L; Madan, T; Kamal, N; Singh, V; Sim, R

• Publication status: Published
• Journal: International immunology
• Volume: 20
• Issue: 8
• Pages: 993-1007
• Publication date: 2008-08-01
• DOI: 10.1093/intimm/dxn058
• EISSN: 1460-2377
• ISSN: 0953-8178
• Language: English
• Keywords: Asthma; Female; Macrophages; Adult; Antigens, Differentiation, T-Lymphocyte; Humans; Cell Line, Tumor; Eosinophils; Recombinant Proteins; Phagocytosis; Lectins, C-Type; Escherichia coli; Apoptosis; Antigens, CD; Up-Regulation; Pulmonary Surfactant-Associated Protein D; Male