Amyotrophic lateral sclerosis: cell vulnerability or system vulnerability?

Journal article

Abstract:: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with clinical, pathological and genetic overlap with frontotemporal dementia (FTD). No longer viewed as one disease with a single unified cause, ALS is now considered to be a clinicopathological syndrome resulting from a complex convergence of genetic susceptibility, age-related loss of cellular homeostasis, and possible environmental influences. The rapid increase in recent years of the number of genes in which mutati...
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Institution:

University of Oxford

Division:

MSD

Department:

Clinical Neurosciences

Role:

Author

Language:: English
Keywords:: Mutation

DNA-Binding Proteins

RNA, Messenger

Humans

Frontotemporal Dementia

Amyotrophic Lateral Sclerosis
Pubs id:: pubs:429369
UUID:: uuid:09a3d5e0-c436-4109-abad-1538aaf752b5
Local pid:: pubs:429369
Source identifiers:: 429369
Deposit date:: 2013-11-16

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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