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Amyotrophic lateral sclerosis: cell vulnerability or system vulnerability?

Abstract:

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with clinical, pathological and genetic overlap with frontotemporal dementia (FTD). No longer viewed as one disease with a single unified cause, ALS is now considered to be a clinicopathological syndrome resulting from a complex convergence of genetic susceptibility, age-related loss of cellular homeostasis, and possible environmental influences. The rapid increase in recent years of the number of genes in which mutati...

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Publisher copy:
10.1111/joa.12107

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Journal of anatomy More from this journal
Volume:
224
Issue:
1
Pages:
45-51
Publication date:
2014-01-01
DOI:
EISSN:
1469-7580
ISSN:
0021-8782
Language:
English
Keywords:
Pubs id:
pubs:429369
UUID:
uuid:09a3d5e0-c436-4109-abad-1538aaf752b5
Local pid:
pubs:429369
Source identifiers:
429369
Deposit date:
2013-11-16

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