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Journal article

Deciphering the genetics of hereditary non-syndromic colorectal cancer.

Abstract:

Previously we have localized to chromosome 3q21-q24, a predisposition locus for colorectal cancer (CRC), through a genome-wide linkage screen (GWLS) of 69 families without familial adenomatous polyposis or hereditary non-polyposis CRC. To further investigate Mendelian susceptibility to CRC, we extended our screen to include a further GWLS of an additional 34 CRC families. We also searched for a disease gene at 3q21-q24 by linkage disequilibrium mapping in 620 familial CRC cases and 960 contro...

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Publication status:
Published

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Publisher copy:
10.1038/ejhg.2008.129

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Journal:
European journal of human genetics : EJHG
Volume:
16
Issue:
12
Pages:
1477-1486
Publication date:
2008-12-01
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Source identifiers:
72068

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