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Journal article

Coregulated human globin genes are frequently in spatial proximity when active

Abstract:

The organization of genes within the nucleus may influence transcription. We have analyzed the nuclear positioning of the coordinately regulated α- and β-globin genes and show that the gene-dense chromatin surrounding the human α-globin genes is frequently decondensed, independent of transcription. Against this background, we show the frequent juxtaposition of active α- and β-globin genes and of homologous α-globin loci that occurs at nuclear speckles and correlates with transcription. Howeve...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1083/jcb.200507073

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, WIMM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, WIMM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, WIMM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, WIMM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, WIMM
Role:
Author
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Medical Research Council More from this funder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
172
Pages:
177-187
Publication date:
2006-01-17
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:099d9464-f2f3-470d-a452-5b21a0b6a3d7
Source identifiers:
344460
Local pid:
pubs:344460

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