Journal article
Coregulated human globin genes are frequently in spatial proximity when active
- Abstract:
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The organization of genes within the nucleus may influence transcription. We have analyzed the nuclear positioning of the coordinately regulated α- and β-globin genes and show that the gene-dense chromatin surrounding the human α-globin genes is frequently decondensed, independent of transcription. Against this background, we show the frequent juxtaposition of active α- and β-globin genes and of homologous α-globin loci that occurs at nuclear speckles and correlates with transcription. Howeve...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.8MB)
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- Publisher copy:
- 10.1083/jcb.200507073
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Authors
Funding
Medical Research Council
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Bibliographic Details
- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Cell Biology Journal website
- Volume:
- 172
- Pages:
- 177-187
- Publication date:
- 2006-01-17
- Acceptance date:
- 2005-12-13
- DOI:
- EISSN:
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1540-8140
- ISSN:
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0021-9525
- Source identifiers:
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344460
Item Description
- Pubs id:
-
pubs:344460
- UUID:
-
uuid:099d9464-f2f3-470d-a452-5b21a0b6a3d7
- Local pid:
- pubs:344460
- Deposit date:
- 2016-03-04
Terms of use
- Copyright holder:
- Rockefeller University Press
- Copyright date:
- 2006
- Notes:
- Copyright © The Rockefeller University Press.
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