- Abstract:
-
The organization of genes within the nucleus may influence transcription. We have analyzed the nuclear positioning of the coordinately regulated α- and β-globin genes and show that the gene-dense chromatin surrounding the human α-globin genes is frequently decondensed, independent of transcription. Against this background, we show the frequent juxtaposition of active α- and β-globin genes and of homologous α-globin loci that occurs at nuclear speckles and correlates with transcription. Howeve...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.8MB)
-
- Publisher copy:
- 10.1083/jcb.200507073
-
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- Publisher:
- Rockefeller University Press Publisher's website
- Journal:
- Journal of Cell Biology Journal website
- Volume:
- 172
- Pages:
- 177-187
- Publication date:
- 2006-01-17
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- URN:
-
uuid:099d9464-f2f3-470d-a452-5b21a0b6a3d7
- Source identifiers:
-
344460
- Local pid:
- pubs:344460
- Copyright holder:
- Rockefeller University Press
- Copyright date:
- 2006
- Notes:
- Copyright © The Rockefeller University Press.
Journal article
Coregulated human globin genes are frequently in spatial proximity when active
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