Journal article
Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis.
- Abstract:
- Copper catalysis allows alkyl zirconium species, generated in situ from alkenes, to undergo conjugate addition reactions. A hydrometallation-catalytic asymmetric 1,4-addition was used to synthesize either enantiomer of a natural product in one step from commercially available materials. Hydrometallation-addition sequences applied to steroids containing a cross-conjugated dienone or 1,6-acceptor give highly functionalized products.
- Publication status:
- Published
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- Publisher copy:
- 10.1039/c2cc37155c
Authors
- Journal:
- Chemical Communications More from this journal
- Volume:
- 49
- Issue:
- 39
- Pages:
- 4211-4213
- Publication date:
- 2013-05-01
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- Language:
-
English
- Pubs id:
-
pubs:365521
- UUID:
-
uuid:099b8c60-958a-4e94-ab5f-31d4efab4d42
- Local pid:
-
pubs:365521
- Source identifiers:
-
365521
- Deposit date:
-
2013-11-17
- ARK identifier:
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- Copyright date:
- 2013
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