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Journal article

Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis.

Abstract:
Copper catalysis allows alkyl zirconium species, generated in situ from alkenes, to undergo conjugate addition reactions. A hydrometallation-catalytic asymmetric 1,4-addition was used to synthesize either enantiomer of a natural product in one step from commercially available materials. Hydrometallation-addition sequences applied to steroids containing a cross-conjugated dienone or 1,6-acceptor give highly functionalized products.
Publication status:
Published

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Publisher copy:
10.1039/c2cc37155c

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemical Communications
Volume:
49
Issue:
39
Pages:
4211-4213
Publication date:
2013-05-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Source identifiers:
365521
Language:
English
Pubs id:
pubs:365521
UUID:
uuid:099b8c60-958a-4e94-ab5f-31d4efab4d42
Local pid:
pubs:365521
Deposit date:
2013-11-17

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