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Studies on the role of calcium in the 5-HT-stimulated release of glutamate from C6 glioma cells.

Abstract:

We recently reported that 5-hydroxytryptamine(2A) (5-HT(2A)) receptor activation on cultured glial cells induces glutamate release [J. Neurosci. Res. 67 (2002) 399]. Here we use C6 glioma cells to examine the role of calcium in this response. 5-Hydroxytryptamine (5-HT) increases glutamate release from C6 glioma cells, an effect blocked by low calcium conditions. The calcium ionophores ionomycin and calcimycin also released glutamate from C6 glioma cells in a Ca(2+)-dependent manner. The effec...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
European journal of pharmacology More from this journal
Volume:
445
Issue:
1-2
Pages:
13-19
Publication date:
2002-06-01
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
Language:
English
Keywords:
Pubs id:
pubs:97974
UUID:
uuid:09970f0a-dcb9-45f6-b0d8-afbf5fd39318
Local pid:
pubs:97974
Source identifiers:
97974
Deposit date:
2012-12-19

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