Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.

Journal article

It is not known how human immunodeficiency virus type 1 (HIV-1)-derived antagonist peptides interfere with intracellular activation of cytotoxic T lymphocytes (CTL). We identified Gag epitope variants in HIV-1-infected patients that act as antagonists of CTL responses to unmutated epitopes. We then investigated the effect that presentation of each variant has on the early events of T cell receptor (TCR) signal transduction. We found that altered peptide ligands (APL) failed to induce phosphor...

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Authors: Purbhoo, M; Sewell, A; Klenerman, P; Goulder, P; Hilyard, K

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 95
• Issue: 8
• Pages: 4527-4532
• Publication date: 1998-04-01
• DOI: 10.1073/pnas.95.8.4527
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Amino Acid Sequence; Epitopes; B-Lymphocytes; Antigen-Presenting Cells; Receptors, Antigen, T-Cell; Cytotoxicity, Immunologic; Recombinant Fusion Proteins; Cell Line; Genetic Variation; Acquired Immunodeficiency Syndrome; Peptide Fragments; Signal Transduction; Gene Products, gag; Humans; Lymphocyte Activation; T-Lymphocytes, Cytotoxic; HIV-1