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Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.

Abstract:

Antigen presentation is a key rate-limiting step in the immune response. Dendritic cells (DCs) have been reported to be the most potent antigen-presenting cells for naïve T cells, but little is known about the biochemical pathways that regulate this function. We here demonstrate that mature murine DC can be infected with adenovirus at high efficiency (>95%) and that an adenovirus transferring the endogenous inhibitor IkappaBalpha blocks nuclear factor-kappa B (NF-kappaB) function in murine...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Scandinavian journal of immunology
Volume:
58
Issue:
2
Pages:
165-172
Publication date:
2003-08-01
DOI:
EISSN:
1365-3083
ISSN:
0300-9475
Source identifiers:
224021
Language:
English
Keywords:
Pubs id:
pubs:224021
UUID:
uuid:098f5f47-2e27-4400-a454-863352de5137
Local pid:
pubs:224021
Deposit date:
2012-12-19

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